Endothelial cells provide the dynamic lining of blood vessels throughout the body and supply many tissue-specific functions, additionally to providing a nonthrombogenic surface for blood cells and conduit for oxygen and nutrient delivery. As could be expected, some endothelial cells are injured or become senescent and are sloughed into the bloodstream and most circulating endothelial cells display evidence of undergoing apoptosis or necrosis. Rare viable circulating endothelial cells that display properties according to those of a progenitor cell for the endothelial lineage. Mesenchymal stem/stromal cells (MSCs) are fibroblastoid cells capable of long-term expansion and skeletogenic differentiation. While MSCs are known to originate from neural crest and mesoderm, immediate mesodermal precursors that produce to MSCs haven't been characterized. A journal may be a periodical publication intended to further progress of science, usually by reporting new research.
