Tumor necrosis is often limited to a small area within the sample. Its presence suggests a more aggressive breast cancer. Hypoxia is a marker of more aggressive tumors and
tumor necrosis was significantly associated with features such as high histologic grade, vascular invasion by
tumor cells and reduced survival.
Tumor necrosis was defined as areas of necrotic
tumor cells immediately adjacent to viable
tumor tissue .Tumor necrosis
factor (TNF) is a multifunctional cytokine that plays important roles in diverse cellular events such as cell survival, proliferation, differentiation, and death. As a pro-inflammatory cytokine, TNF is secreted by inflammatory cells, which may be involved in inflammation-associated carcinogenesis. A malignant wound can result from
tumor necrosis, fungating
tumor cells, an ulcerating cancerous wound, or a malignant cutaneous wound. One of multiple proteins capable of inducing necrosis (death) of
tumor cells that possess a wide range of proinflammatory actions.Because most
tumor cells are genetically limited in apoptotic pathways and prone to necrotic cell death. Tumour necrosis
factor (TNF), a naturally occurring protein that is produced in the human body by the phagocytic
cells known as macrophages. The
tumor necrosis
factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. The
tumor necrosis
factor (TNF) superfamily, composed of 19 ligands and 29 receptors, plays highly diversified roles in the body.
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