Chunyan Liu
Beijing Children�s Hospital, Capital Medical University, China
Scientific Tracks Abstracts: J Antivir Antiretrovir
Human adenoviruses (HAdV) play a significant role in pediatric respiratory tract infections. To date, over 60 types of HAdV have been identified. Respiratory specimens were collected from pediatric patients with ALRTIs in the emergency department or from those admitted to Beijing Children�s Hospital between March 2007 and December 2012. Infections with common respiratory viruses were determined by PCR or RT-PCR. HAdV positive samples were further typed by PCR and sequencing. Among 3356 patients with ALRTIs, 194 (5.8%) were found to have HAdV infection. HAdV infection was primarily confined to children (88.35%) less than 5 years of age. A total of 11 different types of HAdV were detected throughout the study period, with HAdV-B7 (49.0%) and HAdV-B3 (26.3%) as the most prevalent types, followed by HAdV-C2 (7.7%) and HAdVC1 (4.6%). Newly emerging and re-emergent types or variants, HAdV-B55, HAdV-C57, and HAdV-B14p1, were identified. Results also included the reported first case of co-infection with HAdV-C2 and HAdV-C57. Clinical entities of patients with single HAdV infection were similar to those with mixed HAdV/respiratory syncytial virus (RSV) infections. Patients with HAdV-B7 infection had longer duration of fever and higher serum levels of muscle enzymes than HAdV-B3-infected patients. During the study period, HAdV-B7 and HAdV-B3 were the predominant types identified in pediatric ALRTIs. HAdV-B7 infection tends to have more severe clinical consequences. The presence of newly emerging types or variants and co-infection with different types of HAdV highlights the need for constant and close surveillance of HAdV infection.
Chunyan Liu, Assistant Researcher, has completed her PhD in 2014 from Capital Medical University. She has been working in Virology Deparment, Beijing Pediatric Research Institute, Beijing Children’s Hospital since 1996. She won the WHO and ESCV fellowship to study at Virolgy Department, Swedish Institute for Infectious Disease Control (SMI) in 2003 and 2004. She has participated in numerous projects and studies in respiratory and virology and published over 20 papers in related aspects. She is the Secretory of China National Clinical Research Center for Respiratory Diseases.
Email: lchunyan73@163.com
