Mostafa M M Hassan
Cairo University, Egypt
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Introduction: Endometriosis is one of the most common benign gynecological diseases, causing pain and infertility in women of reproductive age. Endometriosis is commonly regarded as a complex trait caused by the interplay between genetic and environmental factors. There is a rapidly increasing interest in identifying genes and genetic polymorphisms that predispose women to increased risk of developing endometriosis. The impetus for evaluating the link of GSTM1 and e-NOS polymorphisms to endometriosis is due to the conclusion that endometriosis, as a chronic inflammatory condition is associated with lack of detoxification and GSTM1 is involved in the two-stage detoxification process while e-NOS may play a role in the development of endometriosis via angio-genetic enhancement. Purpose: To evaluate the impact of GSTM1 & e-NOS gene polymorphism on development of endometriosis among Egyptian females. Methods: Eighty eight women with an endoscopic diagnosis of endometriosis and 80 age matched normal females were included in this study. GSTM1 null polymorphism and e-NOS (Glu298Asp) gene polymorphism were evaluated using conventional PCR technique. Results: Results have shown statistically significant differences of GSTM1 null genotype frequency among cases and control groups while no statistically significant difference was observed as regards genotype distribution of the Glu298Asp polymorphism between women with and without endometriosis. Conclusion: This study showed the presence of association between GSTM1 gene polymorphism and risk of endometriosis in Egyptian population. Genetic associations are often inconsistent across ethnic barriers. The results of this study provide the rationale for further studies with larger sample sizes and in different ethnic populations.
