Rondon Lusliany Josefina, Marcano Eunice, Rodriguez Fatima and Del Castillo Jesus Rafael
Venezuelan Institute for Scientific Research, Venezuela
Posters & Accepted Abstracts: J Clin Exp Cardiolog
The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increase arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility and vascular tone. To evaluate the relationship between high BP induced by a high sodium(Na) diet and Mg and other mineral balances, two experimental rat models of salt-sensitive, induced-hypertension were used: Ang-II infusion and Dahl salt-sensitive (SS) rats. We found that: 1) Ang-II infusion progressively increased BP, which was accompanied by hypomagnesuria and signs of secondary hyperaldosteronism; 2) an additive effect between Ang-II and a high Na load may have an effect on strontium (Sr), zinc (Zn) and copper (Cu) balances; 3) Dahl SSrats fed a high Na diet had a slow pressor response, accompanied by altered Mg, Na, potassium (K), and phosphate (P) balances; and 4) losartan prevented BP increases induced by Ang II-NaCl, but did not modify mineral balances. In Dahl SS rats, losartan attenuated high BP and ameliorated magnesemia, Na and K balances. Mg metabolism may be considered a possible defect in this strain, which may contribute to hypertension.
Email: ljrondon@ivic.gob.ve
