Lauren de Freitas
University of Toronto, Canada
Posters & Accepted Abstracts: J Neurol Neurophysiol
Cannabis is the most widely used substance in the world with Canadian youth aged 15-24 using this substance at a rate three times higher to that of the adult population (24.4% vs. 8.0%). This is especially important when considering the recent growing attention around enacting policy and legislation for the use of cannabis for medicinal and recreational purposes especially in North America. There have been conflicting findings in the literature regarding CBDâ??s efficacy in attenuating delta- 9-tetrahydrocannabinol (THC)-induced adverse effects such as anxiety, paranoia and deficits in cognition as well as cannabidiol (CBD)â??s effects on THCâ??s rewarding properties. Much of the data examining these interactive effects comes from preclinical models. It is imperative to examine CBDâ??s capability in reducing harms incurred, particularly from vulnerable populations, from THC while still providing the benefits that users seek from cannabis. A systematic review and meta-analysis of the literature is being conducted to analyze randomized controlled trials that include healthy volunteers and medical populations. Studies that were included compare strains with CBD and THC together to THC-only or high-THC and low-CBD strains (in 2:1 ratio of THC:CBD or lower). Outcome measures being analyzed. Specifically, can CBD attenuate THC-induced adverse effects, including: (1) Subjective effects (wanting and craving of the drug, frequency of use), (2) physiological effects (heart rate and blood pressure), (3) cognitive effects (memory, psychomotor and cognitive performance) and (4) psychological effects (positive psychotic symptoms, paranoia and anxiety). This emerging area of research informs clinical and policy decisions on the effects of cannabis for recreational and medicinal purposes.
E-mail: lauren.defreitas@mail.utoronto.ca
