Onoja U S
University of Nigeria, Nigeria
Posters & Accepted Abstracts: J Nutr Food Sci
The effect of Triplochiton scleroxylon leaf powder on blood glucose and other biochemical parameters in alloxan-induced diabetic albino rats was investigated. Diabetes was induced by a single administration of Alloxan monohydrate (110 mg/kgBW). Rats with blood glucose â?¥200 mmol/L were confirmed diabetic and used for the study. Forty (40) male albino rats were randomly assigned into four groups of 10 rats each (n=10). The first group received distilled water, while the other groups were treated with 0.5, 1 and 2 g/kgBW of the leaf powder for 90d. Serum glucose, proteins, biochemical parameters, liver and kidney enzyme functions were determined. There was a mean 66.24% decrease in fasting blood glucose in treated diabetic group compared to 14.16% increases in the untreated diabetic group. The T. scleroxylon caused significant increases in WBC, PCV and RBC; however, there were no significant increases in the hemoglobin of the rats. The treated animals exhibited decreases (P>0.05) in both total cholesterol and triglycerides except the group fed 0.5 g/kgBW that had slight increase in triglycerides. The groups that were fed 1 g and 2 g/kgBW respectively, had the highest significant (P<0.05) increases in HDL. Conversely, leaf powder exhibited a dose-dependent decrease in LDL levels. There was a general decrease in liver enzyme activities in all the groups throughout the 90d supplementation. The study revealed that T. scleroxylon leaf powder is safe in the treatment of diabetes, lowering lipid profiles, enhanced hematological parameters and had no adverse effect on both liver and kidney enzymes over the long period of administration.
