Soo Hyun Kim, Ah Reum Lee, Su Ji Kim, Joon Young Choi and Seong-Soo Roh
Daegu Haany University, Republic of Korea
Sae Earl Bio Food co. Ltd., Republic of Korea
Posters & Accepted Abstracts: Med Aromat Plants
Advanced Glycation End product (AGEs) is bind formation of glucose and protein. Acceleration of AGE formation during hyperglycemia is associated with the pathogenesis of diabetic complications and causes kidney and skin damage. The aim of this study was comparison investigated the AGEs inhibitory activity and antioxidant activity of water extracts from Paeoniae Radix Alba (PR) and heated Paeoniae Radix Alba (HPR). HPR was made by heating and roasting with 30% ethanol. AGEs formation inhibitory activities of PR and HPR measured using bovine serum albumin. To evaluate the protective effects of PR and HPR in diabetic rats induced with streptozotocin (STZ) and Methyl Glyoxal (MGO), SD rats were distributed into four groups: Normal rats (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 mg/kg PR (PR) and AGEs-induced rats with 100 mg/kg HPR (HPR) for 3 weeks. HPR respectively decrease AGEs construction compared to Con. HPR administration inhibited the biomarkers of AGEs in serum, kidney and skin tissues. AGE-induced rats revealed that the significant decreased collagen, however; heat processed PR up-regulated collagen through suppress AGEs accumulation. The expressions of inflammatory cytokine were decreased in PR treated group and HPR treated group compared with the control group. These indicate that HPR has a potential to serve as a down regulator on AGEs. In conclusion, it has proposed that may have an alleviating effect on diabetic complications, HPR has more excellent AGEs inhibitory activity and antioxidant compared to PR.
Soo Hyun Kim is a student at Daegu Haany University, South Korea. Seong-Soo Roh has lectured and studied Pharmacology and Toxicity in Korean Medicine at Daegu Haany University. In addition to natural drug research, he is also focusing on research on functional food ingredients and natural cosmetic materials. Presently he is the Editor-in-Chief of The Korea Association of Herbology and serves as an Academic Member and Editor of internationally renowned journals.
