Mahdieh Niknam
Shahid Beheshti University of Medical Sciences, Iran
Posters-Accepted Abstracts: J Glycomics Lipidomics
Atherosclerosis, with its major manifestation, coronary artery disease (CAD) is a chronic inflammatory disease. Dietary fatty acids intakes favorably effect on inflammatory responses. This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (ILâ��6) and high sensitivity Câ��reactive protein (hsâ��CRP), in CAD patients among Iranian population. This hospitalâ��based, crossâ��sectional study was conducted in Chamran Heart Hospital, Isfahan, Iran in 2012. Patients aged â�¥45 years with first ever symptomatic CAD confirmed by angiography were included. A semiâ��quantitative food frequency questionnaire (FFQ) was used to assess the usual intakes of dietary fatty acids. The energyâ��adjusted daily intakes (mean �± SD) of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), linoleic acid, aâ��linolenic acid, and eicosapentaenoic acid and docosahexaenoic acid (EPA + DHA) were 27 �± 9, 22 �± 6, 21 �± 5, 0.4 �± 0.32, and 0.85 �± 0.82 g/d; respectively. After adjustment for potential confounders, SFA was directly related to hsâ��CRP (P = 0.01) and ILâ��6 (P < 0.001) concentrations. Intakes of EPA+DHA and MUFA, were significantly adversely related to plasma hsâ��CRP concentration (P = 0.002 and 0.001, respectively) but not ILâ��6, albeit MUFA was modestly inversely related to ILâ��6 (P = 0.08). No significant relationships were observed for other fatty acids, aâ��linolenic acid, and linoleic acid. These findings suggest that saturated fatty acids, EPA + DHA and MUFA were significantly related to plasma inflammatory markers in CAD patients.
Email: ma_niknam@yahoo.com
