Dian Nurmansyah
Borneo Lestari Institute of Health Science, Indonesia
Posters & Accepted Abstracts: J Drug Metab Toxicol
Typhoid fever is a foodborne disease caused by Salmonella enterica serovar typhi (S. typhi). During S.typhi infection the enzyme transaminase will increase due to damaged hepatocyte, and the patient will be carrier if not treated properly. Earthworms (L. rubellus) contains many compounds including Lumbricin I, G-90 glycoprotein, and Poliphenolic as antimicrobial, antioxidant, and hepatoprotective action in bacterial infections. This study aims to prove that the earthworms extract (L. rubellus) decreased the levels of aminotransaminase enzyme and the number of bacterial colonies in rat infected by S. typhi. This study was an experimental animal model with post-test only control group design. A total of 28 wistar rat were divided into 4 groups (2 controls and 2 treatment groups). The dose of earthworm (L. rubellus) extract is 100mg/kg, the concentration of bacterium S. typhi is 105. Transaminase enzyme measurements performed using IFCC method, and the number of bacterial colony determined using total plate count method. The result showed that the number of bacterial colony in 2 treatment groups is lower than positive control groups. Earthworm (L. rubellus) extract decrease ainotransaminase enzyme levels and the number of bacterial colony on wistar rat were infected S.typhi aakbl.dian@gmail.com
