Keerthi T R, Anjali Ann Jacob, Anu P Sebastian, Honey Chandran C and Akhila Sanker
Posters-Accepted Abstracts: J Clin Cell Immunol
Innate immunity is the protection that living beings obtain by virtue of birth. The scientific community has been investigating new approaches which can enhance innate immune mechanisms to fight against pathogens and thereby reducing the risk of drug resistant strains. These newer approaches take into consideration of neutraceutical products and the prominent among this group is probiotics. The role of probiotic bacteria in modulating immune system has been studied extensively by researchers worldwide.The present topic has been aimed at examining role of bacteria with probiotic capabilities isolated from natural sources in modulating innate immunity. Bacillus subtilis MBTU-PBBM1 isolated from cowâ??s milk was found to enhance both humoral and cell mediated immune response in balb/c mice and the result was found to be dose dependent. Spore forming property of the strain makes it a suitable probiotic candidate during product manufacture.Oral administration of the potential probiotic strain, Enterococcus faecium MBTU-P1F1 isolated from infant faeces stimulated phagocytic activity of peritoneal macrophages significantly in balb/c mice. The source of origin of the strain finds consideration especially during formulation of probiotic products for human use. The human origin will enable the strain to perform optimally as most health promoting benefits are species specific.The lactic acid bacteria, Lactobacillus plantarum MBTU-P1H1 isolated from honeybee gut flora has essential probiotic properties. Oral treatment of balb/c mice enhanced both humoral and cell mediated immunity. Honey bee gut flora is a rich natural source of lactic acid bacteria and these bacteria are being explored for their varied neutraceutical applications.
