Thais Helena Gasparoto
Posters-Accepted Abstracts: J Clin Cell Immunol
This work will address the expression of receptors on neutrophils involved with immune response triggers by PAMPs and DAMPs. Neutrophils exhibit changes related to their function against diseases during the immunosenescence. However, contradictory data have showna proinflammatory as well as an anti-inflammatory deviation of the immune response in the immunsenescence. Although diseases are in the center of the immune response because different types of attack will result in different mechanisms of the immunity, characteristics of the cells will predict the protection or susceptibility. In the microenvironment of a lesion, the presence of several soluble factors can activate or deactivate inflammatory cells. The direction of the immune response, therefore, is determined through the effects of such factors in these cells. We have analyzed expression of PRRs on neutrophils obtained from elderly subjects in the presence of inflammatory and anti-inflammatory factors. Ability of these cells to destroy bacteria and yeasts has been determined. Our results might help to elucidate the immunosenescence events.
