Atin Singhai, Suresh Babu and Nishant Verma
King George�s Medical University, India
Scientific Tracks Abstracts: J Leuk
International Society of Pediatric Oncology (SIOP) grading of childhood renal tumors receiving preoperative chemotherapy judiciously delineates subclasses and subgroups as per chemotherapy induced changes which further guides the clinicians for planning further course of management. A total of 32 cases were enrolled in our study, of which 23 received preoperative chemotherapy while 9 underwent upfront nephrectomy. All were clinico-radiologically suspicious for nephroblastoma however 4 turned out to have different histological diagnosis viz clear cell sarcoma of kidney (CCSK) in two and one each rhabdoid tumor and neuroblastoma respectively. All nine cases of upfront nephrectomy were histologically nephroblastoma and designated as controls. Significant response of epithelial and stromal elements to chemotherapy as per SIOP protocol was noted as against controls. However, blastoma predominant and diffuse anaplasia variants as well as other high risk tumors like CCSK, rhabdoid tumor and neuroblastoma had nil or minimal response and had to be considered for further chemotherapy. To conclude, management of childhood renal tumors especially nephroblastoma by SIOP protocol not only offers efficient reduction in viable tumor load but also demarcates high risk cases which require further chemotherapy.
Atin Singhai is an Associate Professor at Department of Pathology, King George’s Medical University, Lucknow, India since 2011. His areas of interest include pediatric oncopathology, nephropathology and uropathology. He has published about 25 papers in journals of international repute also presented more than 15 guest lectures in various conferences across India.
