Navpreet Kaur and Randhir Singh
M.M. University, India
Posters-Accepted Abstracts: Endocrinol Metab Syndr
Diabetic nephropathy is a chronic complication of diabetes mellitus which leads to end-stage renal disease. Dillenia indica L. (Family: Dilleniaceae) is widely used in traditional medicine to treat various diseases including diabetes. The present study was designed to evaluate the effect of hydro-alcohol extract of D. indica leaves in diabetic nephropathy in rats. Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin (65 mg/kg) 15 min after Nicotinamide (230 mg/kg, i.p.) administration. Rats were divided into six groups (n=6). Group 1 and 2 were kept normal control and diabetic control respectively whereas Groups 3�5 consist of diabetic nephropathy rats treated with different doses of extract (100, 200 and 400 mg/kg) for 45 days. Glimipride (10 mg/ kg) was used as positive control. Diabetic nephropathy was assessed by determining serum glucose, insulin, urea, uric acid, creatinine level and tissue histological examination. Tissue antioxidant enzymes (SOD, CAT, GSH, LPO) level was measured to assess the oxidative stress. Hydro-alcohol extracts of D. indica produced significant attenuation in the biochemical parameters used to assess diabetic nephropathy. Elevated serum blood glucose level was significantly reduced. Moreover, level of antioxidant enzymes was also found to be significantly augmented. So, it can be concluded that hydro-alcohol extracts of D. indica have protective effect against diabetic nephropathy.
Email: nav.dhillon1617@gmail.com
