A Y Arkhipov
RAS - Institute of Higher Nervous Activity and Neurophysiology, Russia
Posters & Accepted Abstracts: Anat Physiol
We elaborated the theory of etiology and pathogenesis of paranoid schizophrenia with positive symptoms (raving, pseudohallucinations etc.). The obtained data have revealed that the disturbance of enzyme GAD67 and protein Reelin exchange are caused by infringement of gene's RELN methylation, resulting to dysfunction of neural networks. Reelin is playing the major role in pruning (elimination) of cortical connections with limbic system. During pruning in schizophrenia the abnormal synapses elimination takes place. In schizophrenia with positive symptoms elimination is weak and excessive quantitative synapses prevail in the brain. This leads to the formation of excessive pathological complex of different mediators (glutamate, GABA, dopamine) in the mesocortical and mesolimbic tracts. In schizophrenia with positive symptoms, the disturbances appear starting from the formation of a pathological local structural�functional unit (module). Therefore, local neural networks cannot conjoin to form large scale circuits required for the transition of excitation to the central and frontal regions of the brain to external or internal stimuli. Psychotic state of schizophrenic patients is accompanied by the process of dis-inhibition of neurons and spread of this activation to neural networks. We believe that excessive dis-inhibition of neurons causes pathological reverberation activity of neural networks, resulting in paradoxical changes revealed in our experiments. These neuro-physiological markers of paranoid schizophrenia with productive symptoms, can be applied to new drug trends and epigenetic therapy, it can also provide early detection of the disease.
Email: arhip76@bk.ru
