Z.R. Khaybullina and I.V. Kosnikova
Republican Specialized Centre of surgery, Uzbekistan
Tashkent Pediatrician Medical Institute, Uzbekistan
Posters & Accepted Abstracts: J Clin Exp Cardiolog
The purpose of the research is studying proimflammatory cytokines: interleykin-6 (IL-6), tumor necrosis factor alpha (TNF-a), C-reactive protein (CRP) and marker of endothelial proliferation and migration - vascular endothelial growth factor (VEGF) levels at an atherosclerosis of various localizations. IL-6, TNF-a, CRP, VEGF was analyzed at 28 patients with a peripheral (in iliac-femoral arterial pool) atherosclerosis (PA) and at 80 patients with coronary atherosclerosis (CA). CRP was made in automatic biochemical analyzer â??VITROS-350â? (Germany). IL-6, TNF-alpha, VEGF were measured using ELISA kits. Results: IL-6 level and CPR was increased both at PA and CA patient, IL-6 - in 12,2 and 9,2 times and CRP - in 3,1 and 2,8 times concerning to the control respectively. There was significant difference in FNO-a concentration between PA and CA patients (p<0,05), it was increased in 1,6 and 2,3 times respectively at PA at CA patients. VEGF level was increased in PA patients at 2, 2 times concerning the CA patients. This data suggest that ischemia of peripheral muscles in PA patientâ??s leads endothelial proliferation and collateral bloodstream, which are more intensive in contrast with CA patients due to VEGF concentration increasing. This data can be used in therapeutic angiogenesis conception development. Conclusion: Proimflammatory cytokines IL-6, TNF-a and CRP were increased both at PA and CA patients, but more intensively at PA. Probably, chronic ischemia of peripheral tissues leads local inflammatory reaction and VEGF expression.
Email: zr-khaybullina@rambler.ru
