Hyeon-Mi Park, Jiwon Yang, Young-Don Son and Seok-Il Hwang
Gachon University Gil Hospital, South Korea
Gachon University, South Korea
Posters & Accepted Abstracts: J Neurol Neurophysiol
Introduction: Hippocampal sclerosis (HS) is one of the most common etiologies of the mesial temporal lobe epilepsy (MTLE) and important target for surgical resection. However, extensive areas of ipsilateral and contralateral brain tissue, more than HS, are seemed to be relevant in epileptogenicity from previous researches. We aimed to investigate functional connectivity of hippocampal sub-region in patients of MTLE with HS. Methods: Nine MTLE (right, n=8; left, n=1) patients with unilateral hippocampal sclerosis were recruited. We obtained T1 and T2* weighted images from 3T MRI (Verio, Siemens, Germany). As a seed region for the hippocampus, 6 ROIs (anterior, middle, posterior; left and right) were manually drawn and the correlation coefficient between the hippocampus and each voxel was calculated. Then, the result of each patient was compared with control group data. Results: Patients had a similar increased or decreased connectivity pattern between lesion (right hippocampus)-ipsilateral regions (right cerebral hemisphere) and non-lesion (left hippocampus) and contralateral regions (right cerebral hemisphere), except one patient with left HS. Hippocampal connectivity change was usually seen in the anterior and middle sub-region. Conclusions: In this study, inconsistent result of increased or decreased connectivity between sclerotic hippocampus and other brain regions was observed. However, connectivity pattern of non-lesion hippocampus followed that pattern of the lesion hippocampus to the ipsilateral brain region. It has limitation to interpret these results due to small subjects; however, we can see the widespread brain functional change ipsilateral to the hippocampal sclerosis and there may be relevant in the epileptogenesis of TLE.
Email: neurohm@gilhospital.com
