N Benkirane-Jessel, L Keller, Q Wagner and P Schwinte
French National Institute of Health and Medical Research, France
Posters & Accepted Abstracts: J Cell Sci Ther
Recently, we have reported an active nanostructured collagen implant reinforced with human stem cells for bone regeneration. In our group, we have reported a Smart Hybrid Materials Equipped with Nano-reservoirs of Therapeutics and stem cells. This unique nanotechnology strategy is used to entrap, protect and stabilize therapeutic agents into polymer coatings acting as nanoreservoirs enrobing nanofibers of implantable membranes. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nano-reservoirs. As cells grow, divide and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. This constitutes the first instance of a smart living nanostructured hybrid membrane for regenerative medicine. The cell contact dependent bioerodible nano-reservoirs described here will permit sustained release of drugs, genes, growth factors, etc., opening a general route to the design of sophisticated cell therapy implants capable of robust and durable regeneration of a broad variety of tissues.
Email: Nadia.jessel@inserm.fr
