Pedro Javier Salas Ambrosio, Ma Josefa Bernad-Bernad and Jes�ºs Gracia Mora
UNAM, Mexico
Posters-Accepted Abstracts: J Pharma Care Health Sys
It has designed new ways of treating cancer, one of which is use of nanoparticles. When synthesized with a magnetic core and coated with molecular imprinted polymer (MIP), they may function as a system targeted drug delivery. Because of this synthesized magnetic nanoparticles coated with acrylates, using doxorubicin as template (NMSPD). Synthesis of magnetite nanoparticle was performed by the co-precipitation method, coated with silicates by tetraethyl orthosilicate hydrolysis to prevent decomposition, and MIP was built by thermal polymerization. In the characterization of nanoparticles was determined particle size, Z potential, spectroscopy ATRFTIR, X-ray diffraction powder, absorption and desorption. Results for nanoparticle size were 10�±0.02 nm by TEM, Z potential was 1.98�±0.06. Infrared analysis showed bands at 3436, 2981, 1616, 1579 and 803 cm-1 by doxorubicin, at 2940, 1729, 1413, 1210, 1113 and 1008 cm-1 by acrilates of MIP, at 1040 and 1151 cm-1 by silicates and 551 cm-1 by magnetite. Diffractogram peaks at 2�¸ were 30.26�°, 35.64�°, 43.31�°, 53.75�°, 57.33�° and 62.87�°, which agrees with the characteristic peaks of magnetite. NMSPD adsorbed 124 mg doxorubicin/g nanoparticles in contrast with no imprinted polymer (NMSP) 109 mg doxorubicin/g nanoparticles and 3.35 times more specific. NMSPD desorbed 56 mg doxorubicin/g nanoparticle at 528 hours in a buffer of phosphates pH=7.4, delivery is kind Fick from a polymer matrix. Conclusions were synthesized and characterized magnetic nanoparticles and may function as a system targeted drug delivery, because are magnetic and delivery is prolonged.
Email: jgracia@unam.mx
