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Usefulness of Wieneke criteria in assessing morphologic character | 34249

Pediatrics & Therapeutics

ISSN - 2161-0665

+44 1478 350008

Usefulness of Wieneke criteria in assessing morphologic characteristics of adrenocortical tumors in children

7th European Pediatrics and Pediatric Surgery

September 14-16, 2016 Amsterdam, Netherlands

Nuru Ahmed Seid and Endris Alkadir Seman

Bahir Dar University, Ethiopia

Posters & Accepted Abstracts: Pediat Therapeut

Abstract :

Purpose: The objective of our study was to compare the Wieneke criteria with the standard Weiss criteria used in adults in assessing malignant potential of adrenocortical tumors (ACTs) in children. Aim: The aim of this study was to document the spectrum of clinic-pathological findings in pediatric ACTs and to apply Wieneke criteria in assessing clinical behavior of these tumors. Methods: This multi-institutional study comprised of 13 children with ACTs from January 2005 to May 2014. Clinical and pathological findings were collected from records. Review and analysis of microscopic features were performed. Each individual tumor was assessed applying the criteria proposed by Wieneke et al and designated benign, intermediate for malignancy or malignant. The adult Weiss criteria were also used in the same cases for comparison. Result: Out of 13 cases, 6 were adreno-cortical adenoma, 7 cases were adreno-cortical carcinoma. Majority (76.9%) presented with endocrine dysfunction. Younger patients were found to be associated with better prognosis. Applying Wieneke criteria, there were 6 adenoma, 6 carcinoma and one case was assigned to intermediate for malignancy group. Applying Weiss criteria on the same cases; 3 cases with benign clinical course were assigned to malignant group. Conclusion: Our study validates the reliability of Wieneke scoring system in assessing malignancy in Pediatric ACTs. We are also studying the role of P53 status and KI 67 index in assessing malignancy in pediatric ACTs which will be concluded later.

Biography :

Email: mishraprafulla_k@rediffmail.com

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