It includes oxidation (via cytochrome P450), reduction, and hydrolysis reactions.phase I reactions convert a parent drug to more polar (water soluble) active metabolites by unmasking or inserting a polar functional group (-OH, -SH, -NH2).
Related Journals of Phase I Drug Metabolism
Journal of Bioequivalence & Bioavailability, Journal of Drug Metabolism & Toxicology, Drug Designing: Open Access, Journal of Metabolic Syndrome, Phase I Drug Metabolism, Drug Metabolism and Pharmacokinetics, Current Drug Metabolism, Expert Opinion on Drug Metabolism & Toxicology, Drug Metabolism Letters, Frontiers in Pharmacology, Nutrition & Metabolism.
